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Also, our prevalence estimate for baseline reduced BMD was dependent on a ease sample of males screening for an HIV avoidance study. Consequently, these benefits may not reflect the prevalence of reduced BMD in the more substantial population of MSM. Our examine used relatively brief stick to-up (maximum 24 months for quick arm participants).
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Additional adhere to-up in larger cohorts is needed to decide regardless of whether extended use of TDF increases fracture chance. Our review is subject matter to some limitations. 1st, this examine was executed in only 1 internet site (San Francisco) in HIV-uninfected guys, the greater part of whom ended up white.
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Several, Three or more, or even 10?mg/kg once daily offered the in?vivo cartilage-protective influence that's witnessed macroscopically. The location associated with drastically changed cartilage surface area had been lowered from the bones regarding rebamipide-treated rats ( Fig.?2). To judge the actual chondroprotective effect of rebamipide, the particular separated knee joint parts through the
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Further studies are needed to determine regardless of whether BMD outcomes of TDF are sustained or development in the course of for a longer time phrase use, and whether these results reverse soon after TDF discontinuation.
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